ELK Biotechnology cPLA2 rabbit pAb
cPLA2 rabbit pAb는 인간, 마우스, 랫트 시료에 반응하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적합하며, 세포 내 막 및 골지체 막에서 칼슘 의존적으로 이동하는 단백질 검출에 사용됩니다. -20°C에서 1년 보관 가능합니다.
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cPLA2 rabbit pAb
제품 개요
cPLA2 rabbit pAb는 인간 c-PLA2 유래 합성 펩타이드(AA 471–520)에 대해 생산된 폴리클로날 항체로, 세포 내 인지질 가수분해 효소의 발현 및 위치 연구에 사용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | cPLA2 rabbit pAb |
| Alternative Names | PLA2G4A; CPLA2; PLA2G4; Cytosolic phospholipase A2; Phospholipase A2 group IVA |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human c-PLA2 (AA range: 471–520) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 110 kDa |
| Gene ID (Human) | 5321 |
| Human Swiss-Prot No. | P47712 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, Golgi apparatus membrane, nuclear envelope. Translocates to intracellular membranes in a calcium-dependent manner. |
Background
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid, which is subsequently metabolized into eicosanoids such as prostaglandins and leukotrienes. These lipid-based cellular hormones regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca²⁺ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. (RefSeq, Jul 2015)
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