ELK Biotechnology PR (phospho Ser400) rabbit pAb
인간 프로게스테론 수용체 Ser400 인산화 부위를 인식하는 polyclonal rabbit 항체로, WB 및 IHC에 적합합니다. 핵과 세포질에서 발현되는 PR 단백질 검출에 사용되며, 높은 특이성과 재현성을 제공합니다.
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제품명
PR (phospho Ser400) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
이 항체는 인간 프로게스테론 수용체(Progesterone Receptor)의 Ser400 인산화 부위를 인식하는 rabbit polyclonal antibody입니다. 생식 관련 신호전달 연구 및 핵-세포질 이동 메커니즘 분석에 적합합니다.
스펙 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PGR; NR3C3; Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3 |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human Progesterone Receptor around phosphorylation site of Ser400 (AA range: 371–420) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 99 kDa |
| GeneID (Human) | 5241 |
| Human Swiss-Prot No | P06401 |
| Cellular Localization | Nucleus, Cytoplasm. Nucleoplasmic shuttling is hormone- and cell cycle-dependent. On hormone stimulation, retained in cytoplasm during G(1) and G(2)/M phases. Isoform A: mainly nuclear; Isoform 4: mitochondrial outer membrane. |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. (provided by RefSeq, Sep 2015)
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