ELK Biotechnology Pepsin C rabbit pAb
Pepsin C rabbit pAb는 인간, 랫, 마우스에 반응하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며, Pepsin C 단백질 검출에 적합합니다. 위점막 및 혈청 내 소화효소 연구에 활용됩니다.
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Pepsin C rabbit pAb
공급업체: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Pepsin C rabbit pAb |
| Alternative Names | PGC; Gastricsin; Pepsinogen C |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Pepsin C. AA range: 257–306 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 42 kD |
| GeneID (Human) | 5225 |
| Human Swiss-Prot No | P20142 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme produced in the stomach and constitutes a major component of the gastric mucosa. It is also secreted into the serum and synthesized as an inactive zymogen with a highly basic prosegment. The enzyme becomes active at low pH through self-cleavage of the prosegment. Polymorphisms in this gene are linked to susceptibility to gastric cancers. Serum levels serve as biomarkers for gastric diseases, including Helicobacter pylori-related gastritis. Alternate splicing produces multiple transcript variants, and a pseudogene exists on chromosome 1. (RefSeq, Oct 2009)
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