Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (LN-3)
HLA-DRB (MHC II) 단백질을 인식하는 LN-3 클론의 마우스 단클론 항체. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 사용 가능. 인간 및 비인간 영장류 반응성. 단백질 A/G 정제, PBS 용액 형태로 제공.
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- 3123-MSM1-P1ABX
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LN-3 |
| Immunogen | Activated human peripheral blood mononuclear cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse.
Target Information
HLA-DR beta refers to the beta chain of the HLA-DR protein complex, a member of the human leukocyte antigen (HLA) class II molecule family. It is encoded by the HLA-DRB gene and is primarily expressed on antigen-presenting cells such as dendritic cells, macrophages, and B cells. These cells are essential for immune recognition by presenting antigens to T cells.
HLA-DR beta plays a critical role in the immune system by facilitating the recognition and response to extracellular antigens. Its extracellular domain contains the peptide-binding groove that interacts with antigenic peptides, while the transmembrane domain anchors it to the cell membrane and the cytoplasmic tail participates in signaling.
HLA and MHC antibodies are also widely used in Immunopeptidomics to identify and characterize neoantigens via high-performance liquid chromatography coupled with tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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