Thermo Fisher Scientific RRAS Polyclonal Antibody

Thermo Fisher Scientific RRAS Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:2,000

Species Reactivity

• Human
• Mouse
• Rat

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total R-Ras.

Target Information

The Ras superfamily of small GTPases includes the Ras, Rho, Arf, Rab, and Ran families. Ras-regulated signaling pathways control actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. These GTPases function as molecular switches that control eukaryotic cell function by cycling between a GDP-bound inactive form and a GTP-bound active form.
Ras proteins are attached to the cell membrane by prenylation. Mutations in Ras family proto-oncogenes (H-Ras, N-Ras, K-Ras) are common, found in 20–30% of all human tumors. K-Ras mutations occur frequently in non-small-cell lung, colorectal, and pancreatic carcinomas; H-Ras mutations are common in bladder, kidney, and thyroid carcinomas; N-Ras mutations are found in melanoma, hepatocellular carcinoma, and hematologic malignancies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지: PA5-106240_RRAS_P10301-1_Rabbit.svg, PA5-106240_RRAS_P10301-1_Rabbit_PDP.jpeg)