Thermo Fisher Scientific GEMIN8 Monoclonal Antibody (OTI5B12), TrueMAB
GEMIN8 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 IHC(P) 검증 완료. 인간 시료에 반응하며, 1 mg/mL 농도의 액상 형태. Affinity chromatography로 정제되었으며, 안정적 보관을 위해 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B12 |
| Immunogen | Full length human recombinant protein of human GEMIN8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), essential components of the spliceosome involved in pre-mRNA splicing. Most spliceosomal snRNPs contain common Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) that form a heptameric ring on the Sm site of small nuclear RNA to create the core snRNP. In the cytosol, Sm proteins are initially trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A. The SMN complex mediates the release of CLNS1A and facilitates the assembly and nuclear transport of core snRNPs.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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