Thermo Fisher Scientific CD81 Chimeric Recombinant Rabbit Monoclonal Antibody (1D6)
CD81 단백질을 표적으로 하는 Thermo Fisher Scientific의 키메라 재조합 토끼 단클론 항체(1D6). 다양한 응용 분야(WB, IHC, ICC, Flow, ELISA 등)에 사용 가능하며, 인간 CD81에 높은 특이성을 보임. HEK293 세포에서 발현된 단클론 항체로, Protein A로 정제된 액상 형태.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chimpanzee, Goat, Human, Sheep |
| Host/Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1D6 |
| Immunogen | Produced by immunizing mice with 5A6-aggregated OCI-LY8 B cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074481 |
Product Specific Information
Specificity: This antibody is specific for human CD81, which is expressed on most tissues except red blood cells and platelets.
Target Information
CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family expressed on most nucleated cells, particularly germinal center B cells.
It forms complexes with tetraspanins, integrins, coreceptors, and MHC molecules, influencing adhesion, activation, proliferation, and differentiation of B and T cells.
In muscle cells, CD81 promotes cell fusion and myotube maintenance. It also acts as a receptor for hepatitis C virus.
CD81 associates with CD19, CD21, Leu 13, and integrins, and antibodies against CD81 show anti-proliferative effects on lymphoid cell lines.
CD81 is located in a tumor-suppressor gene region and is considered a candidate gene for malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(해당 항체의 항원 구조 이미지: MA5-48038_CD81_P60033-1_Rabbit.svg, MA5-48038_CD81_P60033-1_Rabbit_PDP.jpeg)
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