Thermo Fisher Scientific Factor XIII A Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
LNVTSVHLFK ERWDTNKVDH HTDKYENNKL IVRRGQSFYV QIDFSRPYDP RRDLFRVEYV IGRYPQENKG TYIPVPIVSE LQSGKWGAKI VMREDRSVRL SIQSSPKCIV GKFRMYVAVW TPYGVLRTSR NPETDT

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency (lack of both A and B subunits) and type II deficiency (lack of the A subunit alone). These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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