Thermo Fisher Scientific MRP1 Recombinant Rabbit Monoclonal Antibody (0J6M2)
MRP1 단백질을 인식하는 토끼 단클론 항체로, Western blot, IHC, ELISA에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 HEK293 세포에서 발현된 재조합 항체입니다. 고순도의 액상 형태로, -20°C에서 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 0J6M2 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 210–304 of human MRP1/ABCC1 (NP_0049872) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.04 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2911910 |
Product Specific Information
- Positive test controls include: A-549
- Immunogen sequence:
ESSASFLSRI TFWWITGLIV RGYRQPLEGS DLWSLNKEDT SEQVVPVLVK NWKKECAKTR KQPVKVVYSS KDPAQPKESS KVDANEEVEA LIVKS
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This full transporter is a member of the MRP subfamily, which is involved in multi-drug resistance. It functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. It also transports glucuronides and sulfate conjugates of steroid hormones and bile salts.
Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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