Thermo Fisher Scientific Phospho-LKB1 (Thr189) Polyclonal Antibody
인간, 생쥐, 랫트에서 반응하는 Rabbit Polyclonal 항체로 Thr189 위치의 인산화된 LKB1 단백질을 검출. WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Protein A로 정제된 액상 형태, 안정적인 저장 및 운송 조건 제공.
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Thermo Fisher Scientific Phospho-LKB1 (Thr189) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human LKB1 around phosphorylation site Thr189 [G(p-T)LK] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
LKB1 (also known as STK11, Serine/threonine-protein kinase STK11) is a tumor suppressor and a member of the serine/threonine kinase family. It physically associates with p53 and regulates specific p53-dependent apoptosis pathways. LKB1 is present in both cytoplasm and nucleus, and translocates to mitochondria during apoptosis. It functions as a master upstream kinase regulating AMPK-related kinases as well as AMPK. Mutations in the LKB1 gene are associated with Peutz-Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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