Thermo Fisher Scientific NKCC2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human NKCC2 (SLC12A1). Validated for IHC (P) at 1:1,000–1:2,500 dilution. High specificity and affinity purified. Suitable for kidney research related to Na-K-Cl cotransporter function.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,500
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SLC12A1. Recombinant protein control fragment (Product #RP-91246). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2647347 |
Product Specific Information
Immunogen sequence:
SQGFDISQVL QVQEELERLE QERLALEATI KDNECEEESG GIRGLFKKAG KLNITKTTPK KDGSINTSQS MHVGEFNQKL VEASTQFKKK QEKGTIDVWW LFDDHighest antigen sequence identity to orthologs:
- Mouse: 87%
- Rat: 86%
Target Information
The sodium-potassium-chloride cotransporter isoform 2 (NKCC2) is kidney-specific and localized on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It mediates NaCl resorption with a stoichiometry of 1Na:1K:2Cl and is sensitive to diuretics such as furosemide and bumetanide. Mutations in this gene can cause Bartter-like syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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