Thermo Fisher Scientific SAPAP3/PSD95BP3 Polyclonal Antibody
SAPAP3/PSD95BP3 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 인간, 생쥐, 랫트 반응성. 단백질 A로 정제된 액상 항체로, -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human SAPAP3 (amino acids 201–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family that specifically interacts with PSD-95/SAP90, a membrane-associated guanylate kinase localized at the postsynaptic density (PSD) in neuronal cells. Like other SAPAP proteins, SAPAP3 functions as an adaptor protein interacting with synaptic scaffolding proteins, cytoskeletal, and signaling components such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2).
Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are mainly detected in cell bodies. Research suggests SAPAP3 may be involved in obsessive-compulsive disorder (OCD); mice lacking SAPAP3 exhibit OCD-like symptoms that can be alleviated by lentiviral-mediated selective expression of SAPAP3 in the striatum.
At least two isoforms are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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