Thermo Fisher Scientific Human SLITRK1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the carboxy terminus of human Slitrk1.
PEP-0589 can be used as a blocking peptide with polyclonal antibody PA5-20469.

Target Information

SLIT and NTRK-like family 1 (Slitrk1) is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1–6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein.
These proteins are also homologous to trk neurotrophin receptors in their intracellular domains.
Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons.
Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of other Slitrk proteins inhibited neurite outgrowth, suggesting their involvement in neurite outgrowth control.
While Slitrk1 variants have been suggested to be associated with Tourette’s Syndrome, it is thought to play only a minor role if at all.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.