Thermo Fisher Scientific Angiopoietin 2 Recombinant Rabbit Monoclonal Antibody (ARC0571)
Angiopoietin 2 단백질을 인식하는 재조합 토끼 단클론 항체로, WB, IHC, ELISA 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 Affinity Chromatography 정제. 안정한 액상 형태로 -20°C에서 보관.
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Thermo Fisher Scientific Angiopoietin 2 Recombinant Rabbit Monoclonal Antibody (ARC0571)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:6,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0571 |
| Immunogen | Synthetic peptide corresponding to amino acids 300–400 of human ANGPT2 (UniProt ID: O15123) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849000 |
Product Specific Information
Immunogen sequence:
LTFPNSTEEI KAYCDMEAGG GGWTIIQRRE DGSVDFQRTW KEYKVGFGNP SGEYWLGNEF VSQLTNQQRY VLKIHLKDWE GNEAYSLYEH FYLSSEELNY R
Target Information
ANG-2 binds to the endothelial cell-specific receptor Tie-2, but unlike ANG-1, it does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and can act either as an agonist or antagonist depending on the physiological and biochemical environment. The signaling interactions of ANG-1, ANG-2, and Tie-2, along with ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein of 480 amino acids, composed of an alpha-helix-rich coiled coil N-terminal domain and a fibrinogen-like C-terminal domain, existing predominantly as a disulfide-linked dimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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