Thermo Fisher Scientific HLA-DR beta Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

-

Immunocytochemistry (ICC/IF)

1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fragment corresponding to a region within amino acids 1 and 266 of HLA DR beta (Uniprot ID#P13762) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HLA-DR beta,uniProtId:P13762-1,ncbiNodeId:9606,antigenRange:1-266,antigenLength:266,antigenImageFileName:PA5-21410_HLA-DR_beta_P13762-1_Rabbit.svg,antigenImageFileNamePDP:PA5-21410_HLA-DR_beta_P13762-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_11157870

Product Specific Information

Recommended positive controls: Raji.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

HLA-DR beta refers to the beta chain of the HLA-DR protein complex, which is a member of the human leukocyte antigen (HLA) class II molecule. The HLA-DR beta chain is encoded by the HLA-DRB gene. HLA-DR beta is primarily on the surface of antigen-presenting cells, including dendritic cells, macrophages, and B cells. These cells play a crucial role in the immune system by capturing, processing, and presenting antigens to T cells for immune recognition. HLA-DR beta is a critical component of the immune system, facilitating the recognition and response to extracellular antigens. Its function in presenting antigenic peptides to CD4+ T cells plays a vital role in the activation of adaptive immune responses. HLA-DR beta consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain contains the peptide-binding groove, which interacts with antigenic peptides. The transmembrane domain anchors the HLA-DR beta chain to the cell membrane, while the cytoplasmic tail is involved in intracellular signaling events.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.