Thermo Fisher Scientific Glycine receptor A1 Polyclonal Antibody
Glycine receptor A1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 IHC 실험에 적합합니다. 사람, 생쥐, 랫트 시료에 반응하며, 합성 펩타이드 항원을 사용하여 제작되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host/Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from amino acid region 29–45 of mouse Glycine receptor subunit alpha 1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and human.
- Specificity: GLRA1.
Target Information
GLRA1 encodes a subunit of the pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system.
Defects in GLRA1 cause startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome.
Multiple transcript variants encoding different isoforms have been identified.
Glycine receptors (GlyR) containing GLRA1 belong to the cys-loop family of ligand-gated ion channels and are responsible for mediating inhibitory glycine effects.
GLRA1 is widely distributed in the CNS, especially in the hippocampus, spinal cord, and brain stem.
Diseases associated with GLRA1 include Hereditary Hyperekplexia 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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