Thermo Fisher Scientific NEDD4 Polyclonal Antibody
Human NEDD4 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체. 4°C 보관, 연구용으로만 사용.
- 카탈로그번호
- A303254A
- 판매단위
- pk
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Thermo Fisher Scientific NEDD4 Polyclonal Antibody
Applications
- Western Blot (WB): 1:2,000–1:10,000
- Immunoprecipitation (IP): 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 825 and 875 of human Neural Precursor Cell Expressed, Developmentally Down-regulated 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains.
It is involved in the degradation pathway of VEGFR-2/KDFR independently of its ubiquitin-ligase activity.
NEDD4 acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, analogous to the Mdm2–p53 interaction.
It is reported to be involved in viral budding and regulation of epithelial Na⁺ channels, contributing to arterial hypertension.
NEDD4 protein localizes to the sarcolemmal region of muscle fibers, and increased expression is observed in unloaded or denervated muscles with decreased Notch1 expression, acting as a downregulator of Notch-1 gene expression.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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