Thermo Fisher Scientific POLR3D Polyclonal Antibody
Human POLR3D 단백질에 특이적인 Rabbit Polyclonal Antibody로, Western blot에 적합하며 높은 순도(>95%)를 가진 항원 친화 크로마토그래피 정제 제품입니다. 연구용으로 BRCA1 관련 단백질 상호작용 연구에 활용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 281–330 of Human POLR3D |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2719191 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
This gene encodes a protein that interacts with the N-terminal region of BRCA1. It shares homology with the two most conserved regions of BRCA1—the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in various proteins that regulate cell growth, including tumor suppressor genes and proto-oncogenes. This protein also contains three tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, suggesting that formation of a stable complex between these proteins may be essential for BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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