Thermo Fisher Scientific EML1 Polyclonal Antibody
EML1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human에 반응하며 Mouse, Rat, Zebrafish에서도 예측 반응성을 보입니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 585–815 of Human EML1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547491 |
Product Specific Information
- Recommended positive controls: A549, HepG2
- Predicted reactivity: Mouse (97%), Rat (99%), Zebrafish (85%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Human echinoderm microtubule-associated protein-like (EML1) is a strong candidate for the Usher syndrome type 1A gene.
Usher syndromes (USHs) are genetic disorders characterized by congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable severity depending on the genetic type.
The disease process involves the entire brain, not limited to the posterior fossa or auditory and visual systems.
USHs are categorized as:
- Type I (USH1A, USH1B, USH1C, USH1D, USH1E, USH1F)
- Type II (USH2A, USH2B)
- Type III (USH3)
Type I is the most severe form. Two transcript variants encoding different isoforms have been identified for this gene.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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