Thermo Fisher Scientific CD68 Monoclonal Antibody (OTI2E2), TrueMAB
CD68 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 IHC(P) 실험에 적합합니다. 인간 시료에 반응하며, 동결건조 형태로 제공됩니다. 트레할로스가 포함된 PBS 버퍼에 보관하며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–319 of human CD68 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed in intracellular lysosomes of monocytes and macrophages, and to a lesser extent in dendritic cells and peripheral blood granulocytes.
It may play a role in phagocytic activity, both in intracellular lysosomal metabolism and extracellular cell-cell or cell-pathogen interactions.
CD68 is expressed by interdigitating reticulum cells in tonsil and in certain histiocytic lymphomas, histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma.
Elevated expression has been observed in CD34+ cells in various human malignancies, including several AML studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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