Thermo Fisher Scientific Alpha Actinin 4/ACTN4 Monoclonal Antibody (93)
Human ACTN4 단백질을 인식하는 mouse monoclonal antibody로, IHC(PFA fixed)에서 1–2 µg/mL 농도로 사용 가능. Unconjugated 형태이며 Protein A/G로 정제됨. PBS buffer에 보관하며 -20°C에서 저장. 세포골격 연구 및 ACTN4 관련 질환 연구에 적합.
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Applications
- Immunohistochemistry (PFA fixed) (IHC (PFA)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 93 |
| Immunogen | Recombinant full-length human ACTN4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Alpha actinins belong to the spectrin gene superfamily, representing a diverse group of cytoskeletal proteins including alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types.
In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it binds actin to the membrane. In skeletal, cardiac, and smooth muscle, isoforms are localized to the Z-disc and analogous dense bodies, anchoring myofibrillar actin filaments.
This gene encodes a nonmuscle alpha actinin isoform concentrated in the cytoplasm and thought to be involved in metastatic processes. Mutations have been associated with focal and segmental glomerulosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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