Thermo Fisher Scientific Apolipoprotein J Polyclonal Antibody
Apolipoprotein J 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody로, Mouse와 Rat에 반응하며 WB 및 ICC/IF에 사용 가능. 고순도 액상 형태로 안정적이며 연구용으로 적합.
- 카탈로그번호
- PA519020
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EKALQEYRRKSRAE) corresponding to the C-terminus amino acids of Clu (aa 435–448) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10986117 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins. It prevents stress-induced aggregation of blood plasma proteins and inhibits amyloid fibril formation by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro).
Does not require ATP and maintains partially unfolded proteins for subsequent refolding by other chaperones such as HSPA8/HSC70.
Secreted isoform 1 protects cells against apoptosis and complement cytolysis. Intracellular isoforms interact with ubiquitin and SCF E3 ubiquitin-protein ligase complexes to promote proteasomal degradation of target proteins.
Modulates NF-kappa-B transcriptional activity, with nuclear isoforms promoting apoptosis and mitochondrial isoforms suppressing BAX-dependent cytochrome c release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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