Thermo Fisher Scientific SOCS7 Polyclonal Antibody
Human SOCS7 단백질을 인식하는 Goat Polyclonal 항체로, Western blot에 최적화되어 있습니다. 합성 펩타이드 면역원으로 제작되었으며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. TBS buffer(pH 7.3, 0.5% BSA) 보존, -20°C에서 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (DAGRKPKLTRTQS) corresponding to the internal amino acids of SOCS7 (aa 260–273) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10977994 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. It functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 also inhibits prolactin, growth hormone, and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm, and reducing their binding to DNA. SOCS7 may act as a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that mediates ubiquitination and proteasomal degradation of target proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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