Thermo Fisher Scientific RAB5 Polyclonal Antibody
Thermo Fisher Scientific의 RAB5 폴리클로날 항체는 인간, 마우스, 랫트 시료에 반응하며 WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 고순도 친화 크로마토그래피로 정제된 비결합형 항체로, 세포막 및 엔도솜 단백질 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–215 of human RAB5A (NP_0041532) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.29 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804783 |
Product Specific Information
Immunogen sequence:
MASRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE STIGAAFLTQ TVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNEESFAR AKNWVKELQR QASPNIVIAL SGNKADLANK RAVDFQEAQS YADDNSLLFM ETSAKTSMNV NEIFMAIAKK LPKNEPQNPG ANSARGRGVD LTEPTQPTRN QCCSN
Positive Samples: HeLa, PC-12, Mouse brain
Cellular Location: Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Early endosome membrane, Lipid-anchor, Melanosome, Membrane, cytosol, ruffle
Target Information
RAB5 belongs to the small GTPase Rab family, key regulators of intracellular membrane trafficking. They control vesicle formation, movement, tethering, and fusion by cycling between inactive GDP-bound and active GTP-bound states.
RAB5A is essential for plasma membrane and early endosome fusion, regulates filopodia extension, exosomal release of SDCBP, CD63, PDCD6IP, syndecan, and maturation of apoptotic cell-containing phagosomes downstream of DYN2 and PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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