Thermo Fisher Scientific STEP Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,500

Product Specifications

Product Specific Information

Immunogen sequence:
PEDRRQSVSR QPSFTYSEWM EEKIEDDFLD LDPVPETPVF DCVMDIKPEA DPTSLTVKSM GL

Target Information

Reversible phosphorylation of tyrosine residues is a key regulatory mechanism for numerous cellular events such as proliferation, differentiation, gene expression, and migration. Abnormalities in tyrosine phosphorylation play a role in the pathogenesis of various human diseases, from cancer to immune deficiencies.

There are at least 107 genes coding for protein tyrosine phosphatases (PTPs) in the human genome. All known PTPs contain a highly conserved 12-amino-acid catalytic domain and are distinguished by additional structural motifs.

• Receptor-like PTPs: exhibit extracellular domains, a single transmembrane region, and one or two intracellular phosphatase domains.
• Nonreceptor cytoplasmic PTPs: contain a single phosphatase domain and additional amino acid sequences homologous to motifs found in other protein classes.

Protein tyrosine phosphatases PTPN5 (STEP), PTPRR, and PTPN7 form a family that specifically inactivates MAPKs (mitogen-activated protein kinases). Multiple forms of STEP exist in the adult rat brain, showing differential enrichment in regions related to cognitive, affective, and motor behaviors. Some isoforms are generated through alternative splicing of a single STEP gene, each with unique intracellular targets and functions.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.