Thermo Fisher Scientific BTRC Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
ALKFMNSSER EDCNNGEPPR KIIPEKNSLR QTYNSCARLC LNQETVCLAS TAMKTENCVA KTKLANGTSS MIVPKQRKLS ASYEKEKELC VKYFEQWSES DQVEFVEHLI SQMCHYQHGH

Target Information

This gene encodes a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box.
The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

F-box proteins are divided into three classes:

• Fbws containing WD-40 domains
• Fbls containing leucine-rich repeats
• Fbxs containing either different protein-protein interaction modules or no recognizable motifs

The protein encoded by this gene belongs to the Fbws class; it contains multiple WD-40 repeats in addition to an F-box.
It is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2, and Drosophila Slimb proteins.
It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery.
It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.