Thermo Fisher Scientific LOX Monoclonal Antibody (OTI5C4), TrueMAB
LOX 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot, IHC, ICC/IF에 사용 가능. 인간, 개, 랫트에 반응하며, 고순도 친화 크로마토그래피 정제. 세포외기질 형성과 종양 전이 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–168 of human LOX produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lysyl oxidase (LOX) is a copper-containing amine oxidase belonging to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extracellular matrix. LOX also functions in developmental regulation, tumor suppression, cell motility, and cellular senescence. The secreted form of LOX contributes to the invasive properties of hypoxic human cancer cells, making it essential for hypoxia-induced metastasis and a potential therapeutic target for preventing and treating metastases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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