Thermo Fisher Scientific CD56/NCAM1/NKH1 (Neuronal Cell Marker) Monoclonal Antibody (NCAM/7520)
인간 CD56/NCAM1 신경세포 표지용 단클론 항체로, IHC(P) 및 Peptide Array에 적합합니다. 마우스 IgG2a, kappa 형이며 단백질 A/G로 정제된 액상 제품입니다. 신경세포 및 신경내분비 종양 연구용으로 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NCAM/7520 |
| Immunogen | Recombinant fragment (around aa400–650) of human NCAM1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human cerebellum, pancreas, or neuroblastoma
- Cellular Location: Cell surface
Target Information
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120–180 kDa.
It is found on T cells and NK cells and is involved in cell migration, axonal growth, pathfinding, and synaptic plasticity.
Polysialic modification reduces CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal-derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma.
It is a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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