Thermo Fisher Scientific CRACC Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: 0.25 µg per million cells

Product Specifications

Product Specific Information

In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human CRACC is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain.
Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway and may play a role in lymphocyte adhesion.
Isoform 3 does not mediate activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro).
SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung, and trachea.
Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines.
Isoform 3 is expressed at a much lower level than isoform 1. There are three named isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.