Thermo Fisher Scientific GRP78 Recombinant Rabbit Monoclonal Antibody (2O7F4)
GRP78 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 Affinity chromatography 정제 및 액상 형태. 세포 항상성 및 단백질 접힘 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:6,000–1:36,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2O7F4 |
| Immunogen | Synthetic peptide corresponding to amino acids 531–630 of human BiP/GRP78 (NP_005338.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.09 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA and 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3094270 |
Product Specific Information
Immunogen sequence:
NRLTPEEIER MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KLGGKLSSED KETMEKAVEE KIEWLESHQD ADIEDFKAKK KELEEIVQPI
Target Information
GRP78 is a 78 kDa glucose-regulated protein belonging to the HSP70 family. It is an endoplasmic reticulum (ER) resident protein that assists in the folding and assembly of newly synthesized secretory and membrane proteins. GRP78 also interacts with misfolded proteins, marking them for degradation. The conserved KDEL sequence at its C-terminus ensures ER protein retention via the KDEL receptor.
GRP78 plays a key role in protein folding, degradation of misfolded proteins, and maintenance of cellular homeostasis. It is implicated in neuroprotection under oxidative stress and serves as a biomarker in hypoglycemia. Reduced GRP78 levels are observed in Alzheimer’s disease and certain PS1 gene mutations. Induction of GRP78 has been linked to antitumor drug resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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