Thermo Fisher Scientific CGREF1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
PKDGVTRPDS EVQHQLLPNP FQPGQEQLGL LQSYLKGLGR TEVQLEHLSR EQVLLYLFAL HDYDQSGQLD GLELLSMLTA ALAPGAANSP TTNPVILIVD KVLETQDLNG DGLMTPAELI NFPGVALRHV EPG

Highest antigen sequence identity to the following orthologs:

• Mouse: 75%
• Rat: 72%

Target Information

CGREF1 (cell growth regulator with EF-hand domain 1), also known as CGR11, is a 301 amino acid secreted protein containing two highly conserved calcium-binding EF-hand domains required for mediating cell-cell adhesion. Induced by p53, CGREF1 inhibits cell growth in various cell lines.
CGREF1 is encoded by a gene located on human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome.
Harlequin ichthyosis (skin deformity) is associated with mutations in the ABCA12 gene, while sitosterolemia is linked to defects in ABCG5 and ABCG8 genes. Alstrom syndrome, a rare recessive disorder, is caused by mutations in the ALMS1 gene on chromosome 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.