Thermo Fisher Scientific CREB1 Polyclonal Antibody
CREB1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, Flow 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. Protein A 정제, 고농도(1 mg/mL) 액상 형태. 연구용 전용, 신경전달 및 신호전달 관련 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:20–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CREB1, amino acids 221–314 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB depends on phosphorylation of serine 133. Phosphorylation occurs via p44/42 MAP kinase, p90RSK, p38 MAP kinase, and MSK1. Although CREB binds DNA regardless of phosphorylation, only the phosphorylated form acts as a transcription factor. CREB binding protein (CBP), a coactivator, interacts with CREB at serine 133. CREB is involved in circadian rhythm synchronization, adipocyte differentiation, and learning and memory. The human CREB1 gene is located on chromosome 2q. Dysregulation of CREB has been linked to Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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