Thermo Fisher Scientific CD73 Polyclonal Antibody
Rabbit polyclonal antibody specific for human CD73. Validated for IHC (paraffin) with 1:10–1:50 dilution. Supplied as liquid, 1.2 mg/mL in PBS with 0.09% sodium azide. Store at 4°C short term or -20°C long term. For research use only.
- 카탈로그번호
- PA511870
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD73 Polyclonal Antibody
Applications
Tested Applications and Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 1–30 of the N-terminal region of human CD73 (NT5E) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion chromatography, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C for short term; for long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2154071 |
Target Information
CD73 (Ecto-5'-nucleotidase, 5'-ribonucleotide phosphohydrolase) catalyzes the conversion of purine 5'-mononucleotides to nucleosides at neutral pH, with AMP as the preferred substrate. It forms a dimer of two identical 70 kDa subunits attached to the plasma membrane via a glycosyl phosphatidylinositol linkage. CD73 serves as a marker of lymphocyte differentiation, and its deficiency is linked to various immunodeficiency diseases. Other 5'-nucleotidase isoforms exist in cytoplasm and lysosomes, distinguishable by substrate specificity, cofactor requirements, and inhibitor sensitivity. The CD73 gene is located on chromosome 6q14–q21, and defects in this gene are associated with joint and arterial calcification and intestinal tuberculosis. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.