Thermo Fisher Scientific Phospho-Ku70 (Ser520) Polyclonal Antibody
Phospho-Ku70 (Ser520) 폴리클로날 항체로, 인산화된 Ku70 단백질의 Ser520 잔기를 특이적으로 인식합니다. Western blot 및 면역형광에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. 1 mg/mL 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human XRCC6 (Accession P12956), corresponding to amino acid residues around phosphorylated Ser520. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816621 |
Product Specific Information
This antibody detects endogenous levels of Ku70 only when phosphorylated at Ser520.
Target Information
XRCC6 is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa.
The complex functions as a single-stranded DNA-dependent ATP-dependent helicase and may be involved in the repair of nonhomologous DNA ends, such as those required for double-strand break repair, transposition, and V(D)J recombination.
High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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