Thermo Fisher Scientific COX-2 Polyclonal Antibody
COX-2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. Western blot, IHC, IP 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 4°C에서 보관하며, 연구용으로만 사용됩니다.
✨AI 추천 연관 상품
AI가 분석한 이 상품과 연관된 추천 상품들을 확인해보세요
연관 상품을 찾고 있습니다...
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 554 and 604 of human Cyclooxygenase-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Sheep and Bovine.
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a key step in prostanoid synthesis and inflammatory prostaglandin production.
This process involves two reactions:
- Cyclooxygenase (COX) converts arachidonate to prostaglandin G2 (PGG2).
- Peroxidase reduces PGG2 to PGH2.
COX2 is constitutively expressed in tissues such as endothelium, kidney, and brain, and is upregulated under pathological conditions like cancer and inflammation.
Up-regulation is associated with increased cell adhesion, phenotypic changes, apoptosis resistance, and tumor angiogenesis.
In cancer cells, COX2 facilitates prostaglandin E2 (PGE2) production, influencing motility, proliferation, and apoptosis resistance.
COX2 activity is naturally inhibited by calcitriol (active Vitamin D) and suppressed by glucocorticoids.
It is a known target of NSAIDs such as aspirin, which reduce inflammation and pain.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
🏷️Thermo Fisher Scientific 상품 둘러보기
동일 브랜드의 다른 상품들을 확인해보세요
Thermo Fisher Scientific
Thermo Fisher Scientific PHF21A Polyclonal Antibody
658,900원
Thermo Fisher Scientific
Thermo Fisher Scientific ZHX2 Polyclonal Antibody
194,600원
Thermo Fisher Scientific
Thermo Fisher Scientific COX-2 Polyclonal Antibody
194,600원
Thermo Fisher Scientific
Thermo Fisher Scientific ZHX2 Polyclonal Antibody
194,600원
Thermo Fisher Scientific
Thermo Fisher Scientific COX-2 Polyclonal Antibody
658,900원
배송/결제/교환/반품 안내
배송 정보
| 기본 배송비 |
| 교환/반품 배송비 |
|
|---|---|---|---|
| 착불 배송비 |
| ||
| 교환/반품 배송비 |
| ||
결제 및 환불 안내
| 결제수단 |
|
|---|---|
| 취소 |
|
| 반품 |
|
| 환급 |
|
교환 및 반품 접수
| 교환 및 반품 접수 기한 |
|
|---|---|
| 교환 및 반품 접수가 가능한 경우 |
|
| 교환 및 반품 접수가 불가능한 경우 |
|
교환 및 반품 신청
| 교환 절차 |
|
|---|---|
| 반품 절차 |
|