Thermo Fisher Scientific ERAS Monoclonal Antibody (OTI2C6), TrueMAB
ERAS 단백질을 인식하는 Mouse Monoclonal 항체로 Western Blot 및 Immunocytochemistry에 적합. Human 시료 반응성, Affinity chromatography로 정제, 1 mg/mL 농도. -20°C 보관, 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C6 |
| Immunogen | Full length human recombinant protein of human ERAS produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The human ERAS gene was initially reported as a processed pseudogene (HRasp, Ha-Ras2), with several base substitutions in coding regions, but was more recently described as potentially encoding a functional human ERAS protein.
The ERAS oncogene supports the tumorigenic growth of embryonic stem cells by producing a constitutively active Ras protein.
ERAS protein has less than 50% amino acid identity with H-Ras, another member of the Ras family, but the key domains essential for Ras function are highly conserved.
The protein also contains amino acid residues identical to those present in active mutants of Ras and causes oncogenic transformation in NIH 3T3 cells.
Human ERAS gene is localized in the chromosomal region Xp11.23.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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