Thermo Fisher Scientific EpCAM Polyclonal Antibody
EpCAM 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot과 Flow Cytometry에 적합하며, 비접합 액상 형태로 제공됩니다. 4°C에서 단기 보관 가능하며, 장기 보관 시 -20°C에서 냉동 보관을 권장합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Flow Cytometry (Flow)
- Tested Dilution: 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 57–85 amino acids from the N-terminal region of human EpCAM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542858 |
Target Information
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in epithelial tissues, with a molecular weight of approximately 40 kDa. It functions as a calcium-independent cell adhesion molecule and influences cell cycle, proliferation, and metabolism by inducing proto-oncogene c-myc and cyclins A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth. Overexpression of Ep-CAM is associated with enhanced epithelial proliferation and is highly expressed in human carcinomas, serving as a marker for epithelial lineage tumors.
Ep-CAM is localized on the basolateral surface of most simple epithelia and various carcinoma types and can distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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