Thermo Fisher Scientific Ataxin 2 Polyclonal Antibody
Human Ataxin 2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, IP 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. 신경퇴행성 질환 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Ataxin 2. Recombinant protein control fragment (Product #RP-91710). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638321 |
Product Specific Information
Immunogen sequence:
EGHSINTREN KYIPPGQRNR EVISWGSGRQ NSPRMGQPGS GSMPSRSTSH TSDFNPNSGS DQRVVNGGVP WPSPCPSPSS RPPSRYQSGP NSLPPRAATP TRPPSRPPSR PSRPPSHPSA HGSPAPVSTM PKRMSSE
Highest antigen sequence identity to orthologs:
- Mouse: 93%
- Rat: 95%
Target Information
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. ADCA has been divided into three groups: types I–III.
Defects in this gene cause spinocerebellar ataxia type 2 (SCA2), belonging to ADCA type I, characterized by cerebellar ataxia with additional clinical features such as optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy, and dementia.
SCA2 results from expansion of a CAG repeat in the coding region of this gene, where longer expansions lead to earlier disease onset. Alternatively spliced transcript variants encoding different isoforms have been identified, though their full-length sequences have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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