Thermo Fisher Scientific Ataxin 2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

Assay-dependent

-

Immunoprecipitation (IP)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Ataxin 2. Recombinant protein control fragment (Product #RP-91710). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Ataxin 2,uniProtId:Q99700-1,ncbiNodeId:9606,antigenRange:482-618,antigenLength:1313,antigenImageFileName:PA5-54183_Ataxin_2_Q99700-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54183_Ataxin_2_Q99700-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638321

Product Specific Information

Immunogen sequence: EGHSINTREN KYIPPGQRNR EVISWGSGRQ NSPRMGQPGS GSMPSRSTSH TSDFNPNSGS DQRVVNGGVP WPSPCPSPSS RPPSRYQSGP NSLPPRAATP TRPPSRPPSR PSRPPSHPSA HGSPAPVSTM PKRMSSE

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 95%.

Target Information

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.