Thermo Fisher Scientific PKD1/2/3/PKC mu Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Target Information

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC. It is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival via NF-kappa-B activation, cell migration, and differentiation through HDAC7 nuclear export. It also regulates cell proliferation via MAPK1/3 (ERK1/2) signaling and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis, and flagellin-stimulated inflammatory response.
Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, suppressing EGF-induced MAPK8/JNK1 activation and JUN phosphorylation.
Phosphorylates RIN1, promoting its interaction with 14-3-3 proteins (YWHAB, YWHAE, YWHAZ) and increasing competition with RAF1 for Ras binding (NRAS, HRAS, KRAS).
Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain Golgi membrane structure and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), it regulates the fission of transport vesicles destined for the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.