Thermo Fisher Scientific Phospho-Insulin Receptor (Tyr1361) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

This affinity purified antibody is directed against human Insulin Receptor. This phospho-specific polyclonal antibody is specific for pY1361 human Insulin Receptor. Reactivity with non-phosphorylated Y1361 is minimal. A BLAST analysis suggests cross-reactivity with antigen based on 100% homology with the immunizing sequence to human, rat, mouse, and Xenopus laevis.

Target Information

The biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of phosphorylation cascades. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These receptors differ in sequence in regions conferring ligand specificity and intracellular signaling domains, resulting in distinct functional outcomes. Defects in the insulin receptor (IR) are associated with insulin resistance syndromes, while IGF-1R defects may cause growth retardation. Both signaling cascades are also implicated in cancer development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.