Thermo Fisher Scientific MRP5 Polyclonal Antibody
Thermo Fisher의 MRP5 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 Rabbit IgG 항체입니다. Western blot, IHC, ICC/IF에 적합하며, ABCC5 단백질의 내인성 발현을 검출합니다. 액상 형태로 -20°C에서 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ABCC5 (Accession O15440), corresponding to amino acid residues M1–R33 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852074 |
Product Specific Information
Antibody detects endogenous levels of total ABCC5.
Target Information
The protein encoded by this gene belongs to the ATP-binding cassette (ABC) transporter superfamily, responsible for transporting various molecules across cellular membranes. It is part of the MRP subfamily involved in multidrug resistance.
This protein functions in the cellular export of cyclic nucleotides, contributing to their degradation and elimination. It provides resistance to thiopurine anticancer drugs (6-mercaptopurine, thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine.
It may play a role in resistance to thiopurines in acute lymphoblastic leukemia and to antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing has been observed, though the full sequence and initiation site remain unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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