Thermo Fisher Scientific FAIM3 Polyclonal Antibody

Thermo Fisher Scientific FAIM3 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:200–1:1,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:100

Product Specifications

Product Specific Information

The antibody detects endogenous levels of total Toso protein.

Target Information

Apoptosis is a key process for maintaining normal tissue homeostasis and function. One of the major signals regulating this process is mediated by activation of the Fas receptor by its ligand. This activation leads to the formation of a Fas-associated death domain (FADD)-containing death-inducing signaling complex and subsequent activation of caspase-8, which triggers downstream effector caspases such as caspase-3 and -7.
Recent studies have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells and transgenic mice renders these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.