Thermo Fisher Scientific CHD8 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human CHD8. Recombinant protein control fragment (Product #RP-106379). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CHD8,uniProtId:Q9HCK8-1,ncbiNodeId:9606,antigenRange:2345-2487,antigenLength:2581,antigenImageFileName:PA5-65706_CHD8_Q9HCK8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65706_CHD8_Q9HCK8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2664847

Product Specific Information

Immunogen sequence: PEFAVDPRFLA YMEDRRKQKW QRCKKNNKAE LNCLGMEPVQ TANSRNGKKG HHTETVFNRV LPGPIAPESS KKRARRMRPD LSKMMALMQG GSTGSLSLHN TFQHSSSGLQ SVSSLGHSSA TSASLPFMPF VMGGAPSSPH VD

Highest antigen sequence identity to the following orthologs - mouse 90%, rat 91%.

Target Information

DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.