Thermo Fisher Scientific KIF3A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Target Information

The kinesins constitute a large family of microtubule-dependent motor proteins responsible for the distribution of organelles, vesicles, and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis.

Members of the heterotrimeric kinesin II family generally contain two different motor subunits from the KIF3 family (KIF3A, KIF3B, KIF3C). KIF3 isoforms mediate anterograde transport of membrane-bound organelles in neurons and melanosomes, as well as transport between the endoplasmic reticulum and the Golgi apparatus. They also transport protein complexes within cilia and flagella required for morphogenesis.

KIF3A may influence neurogenesis during embryonic development, particularly in left-right axis determination. Loss of KIF3A function in mouse photoreceptors leads to apoptotic cell death, indicating that kinesin II-mediated transport is essential for proper cell fate determination.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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