Thermo Fisher Scientific TOP3A Polyclonal Antibody
TOP3A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 면역형광(ICC/IF)에 적합하며, 인간과 생쥐 시료 반응. 고순도 친화 크로마토그래피 정제, -20°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: References
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TOP3A (Accession Q13472), corresponding to amino acid residues D953–R1001 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815882 |
Product Specific Information
Antibody detects endogenous levels of total TOP3A.
Target Information
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands.
Although DNA topoisomerase I (Topo I) and Topo II relax both positive and negative supercoils, Topo III relaxes only negative supercoils.
Topo IIIα exists as long and short isoforms produced by alternative splicing. It localizes to the nucleolus and remains at high levels throughout the cell cycle in HL-60 cells.
Topo IIIβ exists as three isoforms (β-1, β-2, β-3), also produced by alternative splicing. Topo IIIβ-1 is expressed in testis, heart, and skeletal muscle, whereas Topo IIIβ-2 is expressed in thymus, kidney, and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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