Thermo Fisher Scientific cGAS Polyclonal Antibody
Thermo Fisher Scientific의 cGAS Polyclonal Antibody는 인간 cGAS 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot, ICC/IF, Flow cytometry에 적합하며, 단백질 A 및 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:25 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 266–295 amino acids from the central region of human CF150 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541512 |
Target Information
cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP, playing a key role in innate immunity. Catalysis involves both the formation of 2’,5’ phosphodiester linkage at the GpA step and the formation of 3’,5’ phosphodiester linkage at the ApG step, producing c[G(2’,5’)pA(3’5’)p] responses.
cGAS binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, which then activates TMEM173/STING and triggers type-I interferon production.
It is also involved in innate immune sensing of infection, detection of bacterial DNA, cellular stress response, DNA damage, and regulation of cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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