Thermo Fisher Scientific Phospho-TCF3 (Thr355) Polyclonal Antibody
Phospho-TCF3 (Thr355) 폴리클로날 항체로, 인산화된 TCF3 단백질 검출에 적합합니다. 인간, 생쥐, 랫드 시료에 반응하며 IHC(P) 실험에 사용 가능합니다. 친화 크로마토그래피로 정제된 고순도 항체로, -20°C에서 보관합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of threonine 355 (P-S-T(p)-P-V) derived from Human E2A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2554361 |
Product Specific Information
- A suggested positive control for IHC is human brain tissue.
Target Information
TCF3 (E2A) is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, such as muscle or early B-cell differentiation.
It forms heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) dimers, binding DNA on E-box motifs (5'-CANNTG-3').
It also binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.
Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases.
Two alternatively spliced human isoforms have been described.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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