Thermo Fisher Scientific c-MAF Recombinant Rabbit Monoclonal Antibody (ARC1954)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:6,000

ELISA

• Tested Concentration: 1 µg/mL

Product Specifications

Product Specific Information

• Positive Samples: 293T, A-549, Raji, Mouse lung, Mouse kidney, Rat spleen, Rat kidney
• Immunogen Sequence:
  LNRQLRGVSK EEVIRLKQKR RTLKNRGYAQ SCRFKRVQQR HVLESEKNQL LQQVDHLKQE ISRLVRERDA YKEKYEKLVS SGFRENGSSS DNPSSPEFFM

Target Information

c-MAF is the cellular counterpart of oncogenic v-maf, belonging to the family of basic region leucine zipper transcription factors.

• The leucine-zipper domain mediates interaction with LRPICD.
• Two forms of human c-maf mRNA exist: long and short.
• Identified in the genome of the acute transforming avian retrovirus AS42.
• c-maf regulates IL-4 expression in Th2 cells, crystalline genes in lens fiber cells, insulin gene in islets, and p53 and L7 through Maf recognition element (MARE) binding.
• It plays a crucial role in Th2 differentiation and lineage-specific hematopoiesis.
• Acts as a transcription factor for IL-10 gene expression in LPS-activated macrophages.
• Chromosomal aberrations involving maf are associated with certain forms of multiple myeloma.
• Expressed in myeloma cell lines and resting monocytes/macrophages.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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