Thermo Fisher Scientific Lymphocyte Activation Gene 3 (LAG3) Monoclonal Antibody (OTI5D8)
인간 LAG3 단백질을 인식하는 마우스 단클론 항체로, Flow Cytometry에 적합합니다. Lyophilized 형태로 제공되며, 재구성 시 1 mg/mL 농도로 사용 가능합니다. T세포 활성 조절 연구에 활용되며, 보존 시 -20°C에서 안정적입니다.
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Thermo Fisher Scientific Lymphocyte Activation Gene 3 (LAG3) Monoclonal Antibody (OTI5D8)
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D8 |
| Immunogen | Full length human recombinant protein of human LAG3 (NP_002277) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended product: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily, homologous to CD4.
It binds MHC class II with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation.
LAG-3 is expressed on activated T cells (including regulatory T cells) and NK cells.
CD8+ T cells typically express LAG-3 at higher levels than CD4+ T cells.
Coexpression of LAG-3 and CD49b identifies Type 1 regulatory T cells (Tr1 cells) in humans and mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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