Thermo Fisher Scientific TRPV1 Polyclonal Antibody
TRPV1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 사용 가능. 인간 시료에 반응하며, 합성 펩타이드를 면역원으로 제작. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용 가능.
- 카탈로그번호
- OST00208W-100UL
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the 4th cytoplasmic loop of human TRPV1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: TRPV1.
Target Information
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons.
It is a non-selective cation channel related to the TRP family (e.g., TRPC3, TRPC6), permeable to calcium, magnesium, and monovalent cations. Structurally, TRPV1 contains six transmembrane domains, a P-loop membrane domain, and three ankyrin repeat domains.
TRPV1 is activated by noxious heat and functions as a transducer of painful thermal stimuli in vivo. It mediates proton influx and may contribute to intracellular acidosis in nociceptive neurons. Expression is mainly in sensory ganglia neurons. Four transcript variants with differences in the 5′ UTR have been described.
Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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